Funds from this grant provide continued operating support to the New York Genome Center (NYGC) in its efforts to strengthen and diversify the bioinformatics community in New York City. Sloan funds will support the NYGC’s plans to develop new infrastructure, methods, and training that it expects will catalyze research insights, empower researchers with new bioinformatics capabilities, and continue to solidify New York City as a genomics and life sciences hub. Over the next three years, the NYGC will continue to develop its bioinformatics capabilities in support of its member institutions, develop a shared computing facility with access to public data sets and state-of-the-art data analysis pipelines, craft new algorithms and techniques in bioinformatics, and train biological and medical researchers in core bioinformatics skills through training courses and in-person and virtual educational sessions. Expected outputs include peer-reviewed publications, updated software packages, a bioinformatics commons and genomic data warehouse, and the training of 50 researchers per year.