The DNA Learning Center, operated by Cold Spring Harbor Laboratory, is the world’s largest provider of student lab instruction in molecular genetics, operating six teaching laboratories in Cold Spring Harbor, Lake Success, and Harlem. More than 265,000 precollege students have conducted hands-on experiments at DNA Learning Center locations since its first teaching lab opened, and each year about 30,000 New York area students receive science enrichment during half-day field trips, in-school visits, and week-long DNA camps administered by the Center.   The Center has also popularized several useful methods for delivering laboratory instruction in genetics to large numbers of teachers and students—including equipment-sharing consortia, mobile vans to carry instructional labs to remote sites, and laboratory field trips.This grant provides partial support for the opening of a new DNA Learning Center location in New York City. The new location will bring high-quality molecular genetics education to an estimated 45,000 New York City students annually, and will provide significant educational opportunities to low-income, minority, and underserved student populations.